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MATHEMATICA
| f[n_, b_] := Block[{k = 10^(n + 1), p = Permutations[ Join[ Table[b, {i, 1, n}], {x}]], c = Complement[Table[j, {j, 0, 9}], {b}], q = {}}, Do[q = Append[q, Replace[p, x -> c[[i]], 2]], {i, 1, 9}]; r = Min[ Select[ FromDigits /@ Flatten[q, 1], PrimeQ[ # ] & ]]; If[r ? Infinity, r, p = Permutations[ Join[ Table[ b, {i, 1, n}], {x, y}]]; q = {}; Do[q = Append[q, Replace[p, {x -> c[[i]], y -> c[[j]]}, 2]], {i, 1, 9}, {j, 1, 9}]; Min[ Select[ FromDigits /@ Flatten[q, 1], PrimeQ[ # ] & ]]]]; Table[ f[n, 2], {n, 1, 18}]
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